Vol 9: Serum Levels of Interleukin-9 Correlate with Negative Prognostic Factors in Extranodal NK-T-Cell Lymphoma.Reportar como inadecuado



 Vol 9: Serum Levels of Interleukin-9 Correlate with Negative Prognostic Factors in Extranodal NK-T-Cell Lymphoma.


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This article is from PLoS ONE, volume 9.AbstractInterleukin-9 IL-9 is more functionally diverse than previously expected, especially with regards to lymphomagenesis. However, the relationship between IL-9 and the clinicopathological features of extranodal NK-T-cell lymphoma is less well established. Patients with this lymphoma in Sun Yat-Sen University Cancer Center between January 2003 and March 2013 were systematically reviewed in an intention-to-treat analysis. Baseline serum IL-9 levels were determined using sandwich enzyme-linked immunosorbent assays. A total of seventy-four patients were enrolled in this study. The mean concentration of serum IL-9 for all patients was 6.48 pg-mL range: 1.38–51.87 pg-mL. Age, B symptoms and local lymph node involvement were found to be related to high serum IL-9 levels. Patients with low IL-9 levels tended to have higher rates of complete remission. Notably, the median progression-free survival PFS and overall survival OS were longer in the low IL-9 level group than in the high IL-9 level group PFS: 68.7 months vs. 28.3 months, P



Autor: Zhang, Jing; Wang, Wei-da; Geng, Qi-rong; Wang, Liang; Chen, Xiao-qin; Liu, Cheng-cheng; Lv, Yue

Fuente: https://archive.org/







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