Vol 8: STAT3, p-STAT3 and HIF-1 are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma.Reportar como inadecuado



 Vol 8: STAT3, p-STAT3 and HIF-1 are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma.


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This article is from Oncology Letters, volume 8.AbstractVasculogenic mimicry VM formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma GAC. The present study aimed to investigate the association between signal transducer and activator of transcription-3 STAT3, phosphor-STAT3 p-STAT3, hypoxia-inducible factor-1α HIF-1α and VM formation in GAC, and discuss their clinical significance and correlation with the prognosis of patients with GAC. The expression levels of STAT3, p-STAT3, HIF-1α and VM were assessed in 60 cases of patients with GAC and 20 cases of patients with gastritis on tissue microarrays by immunohistochemical methods. The expression levels of STAT3, p-STAT3, HIF-1α and VM were higher in patients with GAC particularly in poorly differentiated GAC than in those with gastritis P



Autor: SONG, YAN-YAN; SUN, LI-DAN; LIU, MIN-LI; LIU, ZHONG-LIANG; CHEN, FEI; ZHANG, YING-ZHE; ZHENG, YAN; ZHANG, JIAN-PING

Fuente: https://archive.org/







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