Vol 10: Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype.Reportar como inadecuado



 Vol 10: Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype.


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This article is from PLoS Genetics, volume 10.AbstractThousands of long intergenic non-coding RNAs lincRNAs are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain MYH genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer.



Autor: Sakakibara, Iori; Santolini, Marc; Ferry, Arnaud; Hakim, Vincent; Maire, Pascal

Fuente: https://archive.org/







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