Vol 4: Side effects of hydroxyurea in patients with Thalassemia major and thalassemia intermedia and sickle cell anemia.Reportar como inadecuado



 Vol 4: Side effects of hydroxyurea in patients with Thalassemia major and thalassemia intermedia and sickle cell anemia.


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This article is from Iranian Journal of Pediatric Hematology and Oncology, volume 4.AbstractBackground: Sickle hemoglobin is the most common abnormal hemoglobin in the United States. Hemoglobin S arises as a result of a single amino acid substitution glutamic acid to valin at position 6 of the β-globine chain.The presence of fetal hemoglobin HbF plays a relatively protective role since a significant amount of HbF interferes with HbS polymerization, the pathogenesis mechanism of the vaso-occlusive symptoms that are the major contributor of the morbidity and mortality of this condition Thalassemia major and thalassemia intermedia have no specific molecular correlate but encompass a wide spectrum of clinical and laboratory abnormalities.Hydroxyurea HU, an s-phase-specific and non-DNA-hypomethylating chemotherapeutic agents is capable of inducing HbF synthesis. Materials and Methods: This study was done on 56 patients, 28 patients with sickle cell anemia SCA and 28 patients with intermediate or major β-thalassemia. Start dose of HU was 10 mg-kg per day and increased by 5 mg-kg per day every 4-6 weeks until toxicity or according to clinical response. Results: The side effects were dermatologic in 39.28%, neurologic 23.2%, gastrointestinal 17.5% and hematologic 10.71% of patients. the statistical analysis didnt show significant relationship between variables such as history of blood transfusion, duration of HU treatment, age of start HU, age of diagnosis, dose of HU and ethnic with occurrence of HU adverse effects. Conclusion: The HU therapy in our patients tolerated well and side effects were minor to moderate, benign and transient.



Autor: Ghasemi, A; Keikhaei, B; Ghodsi, R

Fuente: https://archive.org/







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