Vol 8: Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease.Reportar como inadecuado



 Vol 8: Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease.


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This article is from Frontiers in Neuroanatomy, volume 8.AbstractCorticospinal motor neurons CSMN have a unique ability to receive, integrate, translate, and transmit the cerebral cortexs input toward spinal cord targets and therefore act as a -spokesperson- for the initiation and modulation of voluntary movements that require cortical input. CSMN degeneration has an immense impact on motor neuron circuitry and is one of the underlying causes of numerous neurodegenerative diseases, such as primary lateral sclerosis PLS, hereditary spastic paraplegia HSP, and amyotrophic lateral sclerosis ALS. In addition, CSMN death results in long-term paralysis in spinal cord injury patients. Detailed cellular analyses are crucial to gain a better understanding of the pathologies underlying CSMN degeneration. However, visualizing and identifying these vulnerable neuron populations in the complex and heterogeneous environment of the cerebral cortex have proved challenging. Here, we will review recent developments and current applications of novel strategies that reveal the cellular and molecular basis of CSMN health and vulnerability. Such studies hold promise for building long-term effective treatment solutions in the near future.



Autor: Jara, Javier H.; Genc, Bar?s; Klessner, Jodi L.; Ozdinler, P. Hande

Fuente: https://archive.org/







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