Vol 14: Role of inflammatory markers in Takayasu arteritis disease monitoring.Reportar como inadecuado



 Vol 14: Role of inflammatory markers in Takayasu arteritis disease monitoring.


Vol 14: Role of inflammatory markers in Takayasu arteritis disease monitoring. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Descargar gratis o leer online en formato PDF el libro: Vol 14: Role of inflammatory markers in Takayasu arteritis disease monitoring.
This article is from BMC Neurology, volume 14.AbstractBackground: Takayasu arteritis TA is an idiopathic large-vessel vasculitis that can result in significant morbidity and mortality secondary to progressive stenosis and occlusion. Monitoring disease progression is crucial to preventing relapse, but is often complicated by the lack of clinical symptoms in the setting of active disease. Although acute phase reactants such as ESR and CRP are generally used as an indicator of inflammation and disease activity, mounting evidence suggests that these markers cannot reliably distinguish active from inactive TA. Case presentation: We report a 24-year-old Hispanic female with a 5-year history of TA who presented with stroke-like symptoms and evidence of left MCA occlusion on imaging, despite a history of decreasing inflammatory markers. CTA revealed complete occlusion of the left common carotid artery, left subclavian, and left MCA from their origins. It also revealed a striking compensatory circulation supplying the left anterior circulation as well as the left subclavian as a response to progressive stenosis. Conclusion: Monitoring ESR and CRP levels alone may not be a reliable method to evaluate disease progression in patients with TA, and should be taken in context with both patient’s clinical picture and the imaging. We recommend that serial imaging be performed regularly in the setting of active disease to monitor progression and allow for immediate therapy in response to evidence of disease advancement, with a relaxation of the imaging interval once the disease is presumed inactive.



Autor: O'Connor, Timothy E; Carpenter, Haley E; Bidari, Sharatchandra; Waters, Michael F; Hedna, Vishnumurthy Shushrutha

Fuente: https://archive.org/







Documentos relacionados