Vol 9: Role of Metformin in Suppressing 1,2-Dimethylhydrazine-Induced Colon Cancer in Diabetic and Non-Diabetic Mice: Effect on Tumor Angiogenesis and Cell Proliferation.Reportar como inadecuado



 Vol 9: Role of Metformin in Suppressing 1,2-Dimethylhydrazine-Induced Colon Cancer in Diabetic and Non-Diabetic Mice: Effect on Tumor Angiogenesis and Cell Proliferation.


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This article is from PLoS ONE, volume 9.AbstractSeveral studies indicated that type 2 diabetes mellitus and insulin resistance are associated with increased colon cancer risk. Recently, studies suggest that metformin can reduce cancer risk in diabetic or non-diabetic patients with unclear mechanisms. This work aimed to determine the effect of metformin on chemically-induced colon cancer in mice. Colon cancer was induced using 1,2-dimethylhydrazine DMH, 20 mg-kg-week, s.c. for fifteen weeks. Experiment I: healthy mice were fed with basal diet for four weeks and then allocated into seven groups, i saline, ii DMH, iii oxaliplatin, iv–v: metformin 100 or 200 mg-kg and vi–vii: oxaliplatin+metformin 100 or 200 mg-kg, respectively. Experiment II: type 2 diabetes mellitus was induced by injection of STZ 30 mg-kg after four weeks of high-fat feeding and then mice were allocated into seven groups similar to those reported in experiment I. Examination of the colonic tissue at the end of the experiment highlighted an increase in angiogenic markers and cell proliferation and showed a greater immunostaining for insulin growth factor I receptors and CD34 in the colon of diabetic mice compared to non-diabetics. In general, metformin downregulated tumor angiogenesis and augmented the antitumor effect of oxaliplatin. Overall, the current results showed that metformin protected against DMH-induced colon cancer in non-diabetic and diabetic mice. This therapeutic effect was, at least in part, attributed to its anti-angiogenic and anti-proliferative mechanisms.



Autor: Zaafar, Dalia K.; Zaitone, Sawsan A.; Moustafa, Yasser M.

Fuente: https://archive.org/







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