Vol 9: Rs964184 APOA5-A4-C3-A1 Is Related to Elevated Plasma Triglyceride Levels, but Not to an Increased Risk for Vascular Events in Patients with Clinically Manifest Vascular Disease.Reportar como inadecuado



 Vol 9: Rs964184 APOA5-A4-C3-A1 Is Related to Elevated Plasma Triglyceride Levels, but Not to an Increased Risk for Vascular Events in Patients with Clinically Manifest Vascular Disease.


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This article is from PLoS ONE, volume 9.AbstractBackground: Single nucleotide polymorphisms in the APOA5-A4-C3-A1 gene complex are associated with elevated plasma triglycerides and elevated vascular risk in healthy populations. In patients with clinically manifest vascular disease, hypertriglyceridemia and metabolic syndrome are frequently present, but the contribution of these single nucleotide polymorphisms to plasma triglycerides, effect modification by obesity and risk of recurrent vascular events is unknown in these patients. Methods: Prospective cohort study of 5547 patients with vascular disease. Rs964184 APOA5-A4-C3-A1 gene complex was genotyped, and we evaluated the relation with plasma lipid levels, presence of metabolic syndrome and the risk for new vascular events. Results: The minor allele of rs964184 was strongly associated with log plasma triglycerides β 0.12; 95%CI 0.10-0.15, p = 1.1*10−19, and was also associated with 0.03 mmol-L lower high-density lipoprotein-cholesterol 95%CI 0.01–0.04, and 0.14 mmol-L higher non-high-density lipoprotein-cholesterol 95%CI 0.09–0.20. The minor allele frequency increased from 10.9% in patients with plasma triglycerides



Autor: van de Woestijne, Anton P.; van der Graaf, Yolanda; de Bakker, Paul I. W.; Asselbergs, Folkert W.; Spiering, Wilko; Visseren, Frank L. J.

Fuente: https://archive.org/



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