Vol 9: Plasma sCD14 as a Biomarker to Predict Pulmonary Exacerbations in Cystic Fibrosis.Reportar como inadecuado



 Vol 9: Plasma sCD14 as a Biomarker to Predict Pulmonary Exacerbations in Cystic Fibrosis.


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This article is from PLoS ONE, volume 9.AbstractBackground: One in four cystic fibrosis CF patients diagnosed with a pulmonary exacerbation will not recover their baseline lung function despite standard treatment. This highlights the importance of preventing such events. Clinical decision-making can be improved through a simple blood test that predicts individuals at elevated short-term risk of an exacerbation. Methods: We obtained plasma samples from 30 stable CF patients from the St. Paul’s Hospital Adult CF Clinic Vancouver, Canada. For 15 patients, an additional plasma sample was obtained during an exacerbation. Soluble CD14 sCD14 and C-reactive protein CRP were quantified using ELISA kits. Myeloperoxidase MPO, interleukinIL-6, IL-1β, monocyte chemoattractant protein-1 MCP-1, vascular endothelial growth factor VEGF, and granulocyte colony-stimulating factor G-CSF were quantified using Luminex™ immunoassays. Stable state biomarker levels were examined in their ability to predict individuals that would experience a pulmonary exacerbation requiring intravenous IV antibiotics within 4 months. Paired stable and exacerbation plasma biomarker levels were also compared. Results: sCD14 levels were significantly higher in patients that experienced a pulmonary exacerbation requiring IV antibiotics within 4 months p = 0.001. sCD14 cut-off value of 1450 ng-mL was associated with an area under the curve of 0.91 95% CI 0.83–0.99 for predicting an exacerbation within 4 months of a stable visit, with a sensitivity of 100% and specificity of 82%. Plasma sCD14 levels were significantly higher during exacerbations than during periods of clinical stability p = 0.03. Conclusions: Plasma sCD14 is a promising biomarker for identifying CF patients who will exacerbate within 4 months of a stable visit but requires further study in larger, independent cohorts.



Autor: Quon, Bradley S.; Ngan, David A.; Wilcox, Pearce G.; Man, S. F. Paul; Sin, Don D.

Fuente: https://archive.org/







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