Vol 86: Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection.Report as inadecuate



 Vol 86: Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection.


Vol 86: Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 86: Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection.
This article is from Annals of Surgical Treatment and Research, volume 86.AbstractPurpose: Because predicting recurrence intervals and patterns would allow for appropriate therapeutic strategies, we evaluated the clinical and pathological characteristics of early and late recurrences of colorectal cancer. Methods: Patients who developed recurrence after undergoing curative resection for colorectal cancer stage I-III between January 2000 and May 2006 were identified. Early recurrence was defined as recurrence within 2 years after primary surgery of colorectal cancer. Analyses were performed to compare the clinicopathological characteristics and overall survival rate between the early and late recurrence groups. Results: One hundred fifty-eight patients experienced early recurrence and 64 had late recurrence. Multivariate analysis revealed that the postoperative elevation of carbohydrate antigen 19-9 CA 19-9, venous invasion, and N stage correlated with the recurrence interval. The liver was the most common site of early recurrence 40.5%, whereas late recurrence was more common locally 28.1%, or in the lung 32.8%. The 5-year overall survival rates for early and late recurrence were significantly different 34.7% vs. 78.8%; P 0.001. Survival rates after the surgical resection of recurrent lesions were not different between the two groups. Conclusion: Early recurrence within 2 years after surgery was associated with poor survival outcomes after colorectal cancer recurrence. An elevated postoperative CA 19-9 level, venous invasion, and advanced N stage were found to be significant risk factors for early recurrence of colorectal cancer.



Author: Ryuk, Jong Pil; Choi, Gyu-Seog; Park, Jun Seok; Kim, Hye Jin; Park, Soo Yeun; Yoon, Ghil Suk; Jun, Soo Han; Kwon, Yong Chul

Source: https://archive.org/







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