Vol 4: Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model.Report as inadecuate



 Vol 4: Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model.


Vol 4: Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 4: Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model.
This article is from Scientific Reports, volume 4.AbstractIschemia-reperfusion IR injury is a cause of pressure ulcer. However, a mechanism underlying the IR injury-induced lymphatic vessel damage remains unclear. We investigated the alterations of structure and function of lymphatic ducts in a mouse cutaneous IR model. And we suggested a new method for evaluating the severity of pressure ulcer. Immunohistochemistry showed that lymphatic ducts were totally vanished by IR injury, while blood vessels were relatively preserved. The production of harmful reactive oxygen species ROS was increased in injured tissue. In vitro study showed a high vulnerability of lymphatic endothelial cells to ROS. Then we evaluated the impaired lymphatic drainage using an in vivo imaging system for intradermally injected indocyanine green ICG. The dysfunction of ICG drainage positively correlated with the severity of subsequent cutaneous changes. Quantification of the lymphatic duct dysfunction by this imaging system could be a useful strategy to estimate the severity of pressure ulcer.



Author: Kasuya, Akira; Sakabe, Jun-ichi; Tokura, Yoshiki

Source: https://archive.org/







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