Vol 29: Prophylactic Effect of Erythropoietin Injection to Prevent Acute Mountain Sickness: An Open-Label Randomized Controlled Trial.Report as inadecuate



 Vol 29: Prophylactic Effect of Erythropoietin Injection to Prevent Acute Mountain Sickness: An Open-Label Randomized Controlled Trial.


Vol 29: Prophylactic Effect of Erythropoietin Injection to Prevent Acute Mountain Sickness: An Open-Label Randomized Controlled Trial. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Journal of Korean Medical Science, volume 29.AbstractThis study was performed to evaluate whether increasing hemoglobin before ascent by prophylactic erythropoietin injections prevents acute mountain sickness AMS. This open-label, randomized, controlled trial involved 39 healthy volunteers with hemoglobin ≤15.5 g-dL who were divided randomly into erythropoietin n=20 and control n=19 groups. Epoetin alpha 10,000 IU injections were given weekly for four consecutive weeks. On day 1, and 7 days after the last injection day 29, oxygen saturation SaO2, and hemoglobin were measured. The subjects departed Seoul on day 30 and arrived at Annapurna base camp ABC, 4,130 m on day 34. AMS was diagnosed when headache and Lake Louise score LLS of ≥3 were present. Immediate descent criteria followed US Army recommendations. Two groups differ in hemoglobin levels on day 29 15.4±1.1 vs 14.2±1.0 g-dL, P=0.001. At ABC, erythropoietin group had a significantly lower mean LLS, AMS incidence, and number of subjects who met immediate descent criteria. Multiple logistic regression analysis showed that SaO2



Author: Heo, Kyoung; Kang, Joong Koo; Choi, Chang Min; Lee, Moo Song; Noh, Kyoung Woo; Kim, Soon Bae

Source: https://archive.org/







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