Vol 5: Phenotype-Based Genetic Association Studies PGAS-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes.Report as inadecuate



 Vol 5: Phenotype-Based Genetic Association Studies PGAS-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes.


Vol 5: Phenotype-Based Genetic Association Studies PGAS-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 5: Phenotype-Based Genetic Association Studies PGAS-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes.
This article is from Genes, volume 5.AbstractNeuropsychiatric diseases ranging from schizophrenia to affective disorders and autism are heritable, highly complex and heterogeneous conditions, diagnosed purely clinically, with no supporting biomarkers or neuroimaging criteria. Relying on these -umbrella diagnoses-, genetic analyses, including genome-wide association studies GWAS, were undertaken but failed to provide insight into the biological basis of these disorders. -Risk genotypes- of unknown significance with low odds ratios of mostly 3000 phenotypical data points per patient, it comprises the world-wide largest currently available schizophrenia database N 1200, combining genome-wide SNP coverage and deep phenotyping under highly standardized conditions. First PGAS results on normal genetic variants, relevant for e.g., cognition or catatonia, demonstrated proof-of-concept. Presently, an autistic subphenotype of schizophrenia is being defined where an unfortunate accumulation of normal genotypes, so-called pro-autistic variants of synaptic genes, explains part of the phenotypical variance. Deep phenotyping and comprehensive clinical data sets, however, are expensive and it may take years before PGAS will complement conventional GWAS approaches in psychiatric genetics.



Author: Ehrenreich, Hannelore; Nave, Klaus-Armin

Source: https://archive.org/







Related documents