Vol 11: Prophylactic and therapeutic effect of AZT-3TC in RT-SHIV infected Chinese-origin rhesus macaques.Report as inadecuate



 Vol 11: Prophylactic and therapeutic effect of AZT-3TC in RT-SHIV infected Chinese-origin rhesus macaques.


Vol 11: Prophylactic and therapeutic effect of AZT-3TC in RT-SHIV infected Chinese-origin rhesus macaques. - Download this document for free, or read online. Document in PDF available to download.

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This article is from AIDS Research and Therapy, volume 11.AbstractBackground: The precise efficacy of nucleoside analogue reverse-transcriptase inhibitors NRTIs in preventing and inhibiting virus replication remains unknown in RT-SHIV infected Chinese-origin rhesus macaques Ch RM. Findings: Ch RM were inoculated intravenously with 200 TCID50 RT-SHIV and treated by gavage with NRTIs 20 mg AZT and 10 mg 3TC twice per day for four consecutive weeks beginning at one hour, on day 217 or 297 post inoculation, respectively. Treatment with AZT-3TC inhibited transiently RT-SHIV replication during chronic infection, but did not significantly affect peripheral blood CD4+ T cells in macaques. Treatment with AZT-3TC at 1 hour post infection prevented RT-SHIV infection in two out of four animals during the 120-day observation period. Conclusions: Therefore, the Ch RM model with RT-SHIV infection can be used to evaluate the efficacy of new NRTIs.



Author: Wang, Wei; Yao, Nan; Cong, Zhe; Jiang, Hong; Qin, Chuan; Wei, Qiang

Source: https://archive.org/







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