Vol 109: Parasite load and risk factors for poor outcome among children with visceral leishmaniasis. A cohort study in Belo Horizonte, Brazil, 2010-2011.Report as inadecuate



 Vol 109: Parasite load and risk factors for poor outcome among children with visceral leishmaniasis. A cohort study in Belo Horizonte, Brazil, 2010-2011.


Vol 109: Parasite load and risk factors for poor outcome among children with visceral leishmaniasis. A cohort study in Belo Horizonte, Brazil, 2010-2011. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Memórias do Instituto Oswaldo Cruz, volume 109.AbstractClinical and laboratory risk factors for death from visceral leishmaniasis VL are relatively known, but quantitative real-time polymerase chain reaction qPCR might assess the role of parasite load in determining clinical outcome. The aim of this study was to identify risk factors, including parasite load in peripheral blood, for VL poor outcome among children. This prospective cohort study evaluated children aged ≤ 12 years old with VL diagnosis at three times: pre-treatment T0, during treatment T1 and post-treatment T2. Forty-eight patients were included and 16 33.3% met the criteria for poor outcome. Age ≤ 12 months relative risk RR 3.51; 95% confidence interval CI 1.89-6.52, tachydyspnoea RR 3.46; 95% CI 2.19-5.47, bacterial infection RR 3.08; 95% CI 1.27-7.48, liver enlargement RR 3.00; 95% CI 1.44-6.23 and low serum albumin RR 7.00; 95% CI 1.80-27.24 were identified as risk factors. qPCR was positive in all patients at T0 and the parasite DNA was undetectable in 76.1% of them at T1 and in 90.7% at T2. There was no statistical association between parasite load at T0 and poor outcome.



Author: Mourao, Maria Vitoria Assumpcao; Toledo, Antonio; Gomes, Luciana Inacia; Freire, Veronica Vieira; Rabello, Ana

Source: https://archive.org/







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