Vol 7: Potential pathway of anti-inflammatory effect by New Zealand honeys.Report as inadecuate



 Vol 7: Potential pathway of anti-inflammatory effect by New Zealand honeys.


Vol 7: Potential pathway of anti-inflammatory effect by New Zealand honeys. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 7: Potential pathway of anti-inflammatory effect by New Zealand honeys.
This article is from International Journal of General Medicine, volume 7.AbstractThe role of honey in wound healing continues to attract worldwide attention. This study examines the anti-inflammatory effect of four honeys on wound healing, to gauge its efficacy as a treatment option. Isolated phenolics and crude extracts from manuka Leptospermum scoparium, kanuka Kunzea ericoides, clover Trifolium spp., and a manuka-kanuka blend of honeys were examined. Anti-inflammatory assays were conducted in HEK-Blue™-2, HEK-Blue™-4, and nucleotide oligomerization domain NOD2-Wild Type NOD2-WT cell lines, to assess the extent to which honey treatment impacts on the inflammatory response and whether the effect was pathway-specific. Kanuka honey, and to a lesser extent manuka honey, produced a powerful anti-inflammatory effect related to their phenolic content. The effect was observed in HEK-Blue™-2 cells using the synthetic tripalmitoylated lipopeptide Pam3CysSerLys4 Pam3CSK4 ligand, suggesting that honey acts specifically through the toll-like receptor TLR1-TLR2 signaling pathway. The manuka-kanuka blend and clover honeys had no significant anti-inflammatory effect in any cell line. The research found that kanuka and manuka honeys have an important role in modulating the inflammatory response associated with wound healing, through a pathway-specific effect. The phenolic content of honey correlates with its effectiveness, although the specific compounds involved remain to be determined.



Author: Tomblin, Victoria; Ferguson, Lynnette R; Han, Dug Yeo; Murray, Pamela; Schlothauer, Ralf

Source: https://archive.org/







Related documents