Vol 16: Protective Role of Endogenous Ovarian Hormones Against Learning and Memory Impairments and Brain Tissues Oxidative Damage Induced by Lipopolysaccharide.Report as inadecuate



 Vol 16: Protective Role of Endogenous Ovarian Hormones Against Learning and Memory Impairments and Brain Tissues Oxidative Damage Induced by Lipopolysaccharide.


Vol 16: Protective Role of Endogenous Ovarian Hormones Against Learning and Memory Impairments and Brain Tissues Oxidative Damage Induced by Lipopolysaccharide. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 16: Protective Role of Endogenous Ovarian Hormones Against Learning and Memory Impairments and Brain Tissues Oxidative Damage Induced by Lipopolysaccharide.
This article is from Iranian Red Crescent Medical Journal, volume 16.AbstractBackground:: The contribution of neuroinflammation in Alzheimer’s disease AD has been widely reported. The effects of female gonadal hormones in both neuroinflammation and brain cognitive functions have also been well considered. Objectives:: In the present study, the possible protective role for endogenous ovarian hormones against learning and memory impairment as well as brain tissues oxidative damage induced by lipopolysachride LPS was investigated in rats. Materials and Methods:: The rats were divided into four groups: Sham-LPS, Ovariectomized OVX-LPS, Sham, and OVX. The animals of sham group were in proestrous phase in which the serum concentration of estradiol is high. The Sham-LPS and OVX-LPS groups were treated with LPS 250 µg-kg before acquisition. The animals were examined using passive avoidance PA test. The brains were then removed and malondialdehyde MDA and total thiol groups concentrations were measured. Results:: The time latency to enter the dark compartment by OVX-LPS group was shorter than that of OVX at both first and 24th hours after the shock P 0.05 - P 0.001. In Sham-LPS and OVX-LPS groups, total thiol concentration in hippocampal and cortical tissues were significantly lower while MDA concentrations were higher than that of Sham and OVX groups P 0.05 - P 0.001. . The hippocampal MDA concentration in OVX-LPS group was higher than Sham- LPS group P 0.01. Conclusions:: Brain tissue oxidative damage contributed in deleterious effects of LPS on learning and memory. Some protective effects for the endogenous ovarian hormones against damaging effects of LPS on learning and memory function, as well as brain tissues oxidative damage could be postulated; however, it needs more investigation.



Author: Pourganji, Masoume; Hosseini, Mahmoud; Soukhtanloo, Mohammad; Zabihi, Hoda; Hadjzadeh, Mosa Al-reza

Source: https://archive.org/







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