Vol 7: Protective effects of the combination of sodium ferulate and oxymatrine on cecal ligation and puncture-induced sepsis in mice.Report as inadecuate



 Vol 7: Protective effects of the combination of sodium ferulate and oxymatrine on cecal ligation and puncture-induced sepsis in mice.


Vol 7: Protective effects of the combination of sodium ferulate and oxymatrine on cecal ligation and puncture-induced sepsis in mice. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Experimental and Therapeutic Medicine, volume 7.AbstractThe aim of this study was to investigate the effects of the combination of sodium ferulate SF and oxymatrine OMT on mice with cecal ligation and puncture CLP-induced sepsis. Swiss male mice were randomly divided into a control group, CLP group, three SF + OMT groups 3.1+6.9; 6.2+13.8 and 12.3+27.7 mg-kg, SF 6.2 mg-kg group and OMT 13.8 mg-kg group. Eight hours after the administration of the drugs, the survival rates and survival times of the animals were monitored. In addition, the lung wet-dry weight W-D ratio; alanine aminotransferase ALT, aspartate aminotransferase AST and lactate dehydrogenase LDH levels in the serum; the C-reactive protein CRP, interleukin-6 IL-6 and interferon-γ IFN-γ levels in the serum and lung and liver homogenates; and the malondialdehyde MDA and superoxidase dismutase SOD levels in the lung and liver homogenates were measured. The bacterial load in the serum was also studied. Following treatment with the combination of SF and OMT, the survival rate increased and the survival time was prolonged; CLP-induced increases in the lung W-D ratio and the levels of ALT, AST, LDH, CRP, IL-6, IFN-γ and MDA were significantly reduced; and the SOD activity levels were increased, compared with those of the untreated animals with CLP-induced sepsis. These results indicated that the combination of SF and OMT induced protective effects against CLP-induced lethal sepsis of mice. The possible mechanism of these effects may be associated with the alleviation of systemic inflammation and diminishment of oxidative injury.



Author: XU, MENGXIN; WANG, WEI; PEI, XIAOKUN; SUN, SONGMEI; XU, MINGBO; LIU, ZHIFENG

Source: https://archive.org/







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