Vol 3: Population Pharmacokinetics of Azithromycin in Whole Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells in Healthy Adults.Report as inadecuate



 Vol 3: Population Pharmacokinetics of Azithromycin in Whole Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells in Healthy Adults.


Vol 3: Population Pharmacokinetics of Azithromycin in Whole Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells in Healthy Adults. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 3: Population Pharmacokinetics of Azithromycin in Whole Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells in Healthy Adults.
This article is from CPT: Pharmacometrics & Systems Pharmacology, volume 3.AbstractAzithromycins extensive distribution to proinflammatory cells, including peripheral blood mononuclear cells PBMCs and polymorphonuclear cells PMNs, may be important to its antimicrobial and anti-inflammatory properties. The need to simultaneously predict azithromycin concentrations in whole blood -blood-, PBMCs, and PMNs motivated this investigation. A single-dose study in 20 healthy adults was conducted, and nonlinear mixed effects modeling was used to simultaneously describe azithromycin concentrations in blood, PBMCs, and PMNs simultaneous PK model. Data were well described by a four-compartment mamillary model. Apparent central clearance and volume of distribution estimates were 67.3 l-hour and 336 l interindividual variability of 114 and 122%, respectively. Bootstrapping and visual predictive checks showed adequate model performance. Azithromycin concentrations in blood, PBMCs, and PMNs from external studies of healthy adults and cystic fibrosis patients were within the 5th and 95th percentiles of model simulations. This novel empirical model can be used to predict azithromycin concentrations in blood, PBMCs, and PMNs with different dosing regimens.



Author: Sampson, M R; Dumitrescu, T P; Brouwer, K L R; Schmith, V D

Source: https://archive.org/







Related documents