Vol 15: Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-B Pathway.Report as inadecuate



 Vol 15: Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-B Pathway.


Vol 15: Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-B Pathway. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 15: Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-B Pathway.
This article is from International Journal of Molecular Sciences, volume 15.AbstractRecent studies have shown that dexmedetomidine exerts an anti-inflammatory effect by reducing serum levels of inflammatory factors, however, the up-stream mechanism is still unknown. The transcription factor NF-κB enters the nucleus and promotes the transcription of its target genes, including those encoding the pro-inflammatory cytokines IL-6 and TNF-α. In this study, we established a rat model that simulates a clinical surgical procedure to investigate the anti-inflammatory effect of perineural administration of dexmedetomidine and the underlying mechanism. Dexmedetomidine reduced the sciatic nerve levels of IL-6 and TNF-α at both the mRNA and protein level. Dexmedetomidine also inhibited the translocation of activated NF-κB to the nucleus and the binding activity of NF-κB. The anti-inflammatory effect is confirmed to be dose-dependent. Finally, pyrrolidine dithiocarbamate also reduced the levels of IL-6 and TNF-α and the activation of NF-κB. In conclusion, dexmedetomidine inhibited the nuclear translocation and binding activity of activated NF-κB, thus reducing inflammatory cytokines.



Author: Huang, Yan; Lu, Yi; Zhang, Lei; Yan, Jia; Jiang, Jue; Jiang, Hong

Source: https://archive.org/







Related documents