Vol 45: Pigs naturally exposed to porcine circovirus type 2 PCV2 generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins.Report as inadecuate



 Vol 45: Pigs naturally exposed to porcine circovirus type 2 PCV2 generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins.


Vol 45: Pigs naturally exposed to porcine circovirus type 2 PCV2 generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 45: Pigs naturally exposed to porcine circovirus type 2 PCV2 generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins.
This article is from Veterinary Research, volume 45.AbstractPorcine circovirus type 2 PCV2 is the essential infectious agent for PCV2-systemic disease PCV2-SD, formerly known as postweaning multisystemic wasting syndrome and other pathological conditions. Recent studies indicated antigenic variability amongst different PCV2 isolates and suggested that single amino acid changes within the capsid protein determine differences in the level of neutralization by specific monoclonal antibodies. The objective of the present study was to examine the cross-reactivity of PCV2 antibodies induced in the context of a natural infection against different PCV2 isolates belonging to genotypes PCV2a and PCV2b. Sera taken from several farms from animals of varying health status PCV2-SD and age-matched healthy pigs and a set of slaughter-aged animals were assayed for neutralizing activity against four PCV2 isolates from both predominant genotypes PCV2a and PCV2b and of differing geographic origins Europe and North-America. Results showed that most of studied pigs 79 out of 82 contained neutralizing antibodies NA able to neutralize all four studied viral strains. Overall, pigs had significantly higher NA titres against PCV2a than against PCV2b P 



Author: Kurtz, Sherry; Grau-Roma, Llorenc; Cortey, Marti; Fort, Maria; Rodriguez, Fernando; Sibila, Marina; Segales, Joaquim

Source: https://archive.org/







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