Vol 9: Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats.Report as inadecuate



 Vol 9: Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats.


Vol 9: Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Journal of Orthopaedic Surgery and Research, volume 9.AbstractBackground: This study aimed to determine whether calcium gluconate exerts protective effects on osteoarthritis OA induced by anterior cruciate ligament ACL transection and partial medial meniscectomy. Methods: Calcium gluconate was administered by mouth daily for 84 days to male ACL transected and partial medial meniscectomized Sprague–Dawley rats 1 week after operation. Results: Eighty-four days of treatment with 50 mg-kg calcium gluconate led to a lower degree of articular stiffness and cartilage damage compared to the OA control, possibly through inhibition of overexpressed cyclooxygenase COX-2 and related chondrocyte apoptosis. Similar favorable effects on stiffness and cartilage were detected in calcium gluconate-administered rats. Additionally, calcium gluconate increased 5-bromo-2′-deoxyuridine BrdU uptake based on observation of BrdU-immunoreactive cells on both the femur and tibia articular surface cartilages 84 days after intra-joint treatment with calcium gluconate. Conclusions: Taken together, our results demonstrate that calcium gluconate has a protective effect against OA through inhibition of COX-2 and related chondrocyte apoptosis.



Author: Kang, Su-Jin; Kim, Joo-Wan; Kim, Ki-Young; Ku, Sae-Kwang; Lee, Young-Joon

Source: https://archive.org/







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