Vol 2: Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastoma.Report as inadecuate



 Vol 2: Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastoma.


Vol 2: Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastoma. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 2: Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastoma.
This article is from Biomedical Reports, volume 2.AbstractRetinoblastoma RB is a childhood malignancy caused by inactivation of the RB gene, with neuron-specific enolase NSE levels considered as its diagnostic marker. MicroRNAs miRNAs have been proven to play a significant role in multiple physiological and pathological processes and several miRNAs were identified as tumor biomarkers in recent studies. In the present study, 65 plasma samples were collected from RB patients and 65 samples from healthy individuals to serve as controls. The miRNA levels were measured via quantitative reverse transcription-polymerase chain reaction and their association with RB was assessed by statistical data analysis and receiver operating characteristic curves. Plasma miRNA miR-320, miR-let-7e and miR-21 levels were downregulated in the patient samples, the areas under the curves AUCs were 0.548–0.660, whereas the AUCs of combined classifiers were ≥0.990. The plasma miRNA levels, particularly of miR-320, were found to be of value in RB diagnosis and may be considered as novel diagnostic biomarkers.



Author: LIU, SHAN-SHAN; WANG, YU-SHI; SUN, YAN-FENG; MIAO, LI-XIA; WANG, JUN; LI, YAN-SHAN; LIU, HONG-YAN; LIU, QIU-LING

Source: https://archive.org/







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