Vol 29: Phenotype Difference between Familial and Sporadic Ankylosing Spondylitis in Korean Patients.Reportar como inadecuado



 Vol 29: Phenotype Difference between Familial and Sporadic Ankylosing Spondylitis in Korean Patients.


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This article is from Journal of Korean Medical Science, volume 29.AbstractClustered occurrences of ankylosing spondylitis AS in family have been noticed. We evaluated patients with AS confirmed by the modified New York criteria for familial history of AS one or more first to third degree relatives. The clinical characteristics and the recurrence risks number of AS patients-number of familial members of the familial AS compared to sporadic AS were investigated. Out of a total of 204 AS patients, 38 patients 18.6% reported that they had a familial history of AS. The recurrence risks in the familial AS patients for first, second and third degree family members were 14.5%, 5.2%, and 4.4% respectively. Erythrocyte sedimentation rate ESR 22.6±22.2 vs 35.4±34.4, P=0.029 and C-reactive protein CRP 1.24±1.7 vs 2.43±3.3, P=0.003 at diagnosis, body mass index 21.9±2.7 vs 23.7±3.3, P=0.002 and frequency of oligoarthritis 13.2% vs 33.7%, P=0.021 were significantly lower in the familial form. The presence of HLA-B27 97.4% vs 83.1%, P=0.044 was significantly higher in familial AS. In conclusion, Korean familial AS patients show a lower frequency of oligoarthritis, lower BMI, lower ESR and CRP at diagnosis and higher presence of HLA-B27.Graphical Abstract:



Autor: Kim, Hye Won; Choe, Hye Rim; Lee, Su Bin; Chang, Won Ik; Chae, Hyun Jun; Moon, Jin Young; Kang, Jisue; Lee, Sungim; Song, Yeong Wook; Lee, Eun Young

Fuente: https://archive.org/







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