Vol 11: Prognostic value of high-sensitivity cardiac troponin T in patients with endomyocardial-biopsy proven cardiac amyloidosis.Reportar como inadecuado



 Vol 11: Prognostic value of high-sensitivity cardiac troponin T in patients with endomyocardial-biopsy proven cardiac amyloidosis.


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This article is from Journal of Geriatric Cardiology : JGC, volume 11.AbstractObjective: To investigate prognostic predictors of long-term survival of patients with cardiac amyloidosis CA, and to determine predictive value of high-sensitivity cardiac troponin T hs-cTnT in CA patients. Methods: We recruited 102 consecutive CA cases and followed these patients for 5 years. We described their clinical characteristics at presentation and used a new, high-sensitivity assay to determine the concentration of cTnT in plasma samples from these patients. Results: The patients with poor prognosis showed older age 56 ± 12 years vs. 50 ± 15 years, P = 0.022, higher incidences of heart failure 36.92% vs. 16.22%, P = 0.041, pericardial effusion 60.00% vs. 35.14%, P = 0.023, greater thickness of interventricular septum IVS 15 ± 4 mm vs. 13 ± 4 mm, P = 0.034, higher level of hs-cTnT 0.186 ± 0.249 ng-mL vs. 0.044 ± 0.055 ng-mL, P = 0.001 and higher NT-proBNP N-terminal pro-B-type natriuretic peptide levels 11,742 ± 10,464 pg-mL vs. 6,031 ± 7,458 pg-mL, P = 0.006. At multivariate Cox regression analysis, heart failure HR: 1.78, 95%CI: 1.09–2.92, P = 0.021, greater wall thickness of IVS HR: 1.44, 95%CI: 1.04–3.01, P = 0.0375 and higher hs-cTnT level HR: 6.16, 95%CI: 2.20–17.24, P = 0.001 at enrollment emerged as independent predictors of all-cause mortality. Conclusions: We showed that hs-cTnT is associated with a very ominous prognosis, and it is also the strongest predictor of all-cause mortality in multivariate analysis. Examination of hs-cTnT concentrations provides valuable prognostic information concerning long-term outcomes.



Autor: Qian, Geng; Wu, Chen; Zhang, Yang; Chen, Yun-Dai; Dong, Wei; Ren, Yi-Hong

Fuente: https://archive.org/







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