Vol 9: Periaortic Brown Adipose Tissue as a Major Determinant of 18F-Fluorodeoxyglucose Vascular Uptake in Atherosclerosis-Prone, ApoE−-− Mice.Reportar como inadecuado



 Vol 9: Periaortic Brown Adipose Tissue as a Major Determinant of 18F-Fluorodeoxyglucose Vascular Uptake in Atherosclerosis-Prone, ApoE−-− Mice.


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This article is from PLoS ONE, volume 9.AbstractBackground: 18F-fluorodeoxyglucose FDG has been suggested for the clinical and experimental imaging of inflammatory atherosclerotic lesions. Significant FDG uptake in brown adipose tissue BAT has been observed both in humans and mice. The objective of the present study was to investigate the influence of periaortic BAT on apolipoprotein E-deficient apoE−-− mouse atherosclerotic lesion imaging with FDG. Methods: ApoE−-− mice 36±2 weeks-old were injected with FDG 12±2 MBq. Control animals Group A, n = 7 were injected conscious and kept awake at room temperature 24°C throughout the accumulation period. In order to minimize tracer activity in periaortic BAT, Group B n = 7 and C n = 6 animals were injected under anaesthesia at 37°C and Group C animals were additionally pre-treated with propranolol. PET-CT acquisitions were performed prior to animal euthanasia and ex vivo analysis of FDG biodistribution. Results: Autoradiographic imaging indicated higher FDG uptake in atherosclerotic lesions than in the normal aortic wall all groups, P



Autor: Toczek, Jakub; Broisat, Alexis; Perret, Pascale; Desruet, Marie-Dominique; Fagret, Daniel; Riou, Laurent M.; Ghezzi, Catherine

Fuente: https://archive.org/







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