Vol 32: Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells.Reportar como inadecuado



 Vol 32: Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells.


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This article is from Oncology Reports, volume 32.AbstractPhloroglucinol is a polyphenolic compound that is used to treat and prevent several human diseases, as it exerts beneficial biological activities, including anti-oxidant, anti-inflammatory and anticancer properties. The aim of the present study was to investigate the effects of phloroglucinol on apoptotic signaling pathways in HT-29 colon cancer cells. The results indicated that phloroglucinol suppressed cell viability and induced apoptosis in HT-29 cells in a concentration-dependent manner. Phloroglucinol treatment of HT-29 cells resulted in characteristic apoptosis-related changes: altered Bcl-2 family proteins, cytochrome c release, and activation of caspase-3 and caspase-8. This study also showed that proteins involved in apoptosis were stimulated by treatment with phloroglucinol. These findings demonstrated that phloroglucinol exerts anticancer activity in HT-29 colon cancer cells through induction of apoptosis.



Autor: KANG, MI-HYE; KIM, IN-HYE; NAM, TAEK-JEO NG

Fuente: https://archive.org/







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