Vol 9: PIK3CA Gene Mutations and Overexpression: Implications for Prognostic Biomarker and Therapeutic Target in Chinese Esophageal Squamous Cell Carcinoma.Reportar como inadecuado



 Vol 9: PIK3CA Gene Mutations and Overexpression: Implications for Prognostic Biomarker and Therapeutic Target in Chinese Esophageal Squamous Cell Carcinoma.


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This article is from PLoS ONE, volume 9.AbstractAims: To evaluate PIK3CA gene mutations and PIK3CA expression status in Chinese esophageal squamous cell carcinoma ESCC patients, and their correlation with clinicopathological characteristics and clinical outcomes. Methods: Direct sequencing was applied to investigate mutations in exons 9 and 20 of PIK3CA in 406 Chinese ESCC patients. PIK3CA expression was evaluated using immunohistochemistry analysis. The associations of PIK3CA gene mutations and PIK3CA expression with clinicopathological characteristics and clinical outcome were examined. Results: Thirty somatic point mutations 30-406, 7.4% were identified in exon 9 whereas no mutations were detected in exon 20. PIK3CA mutations were not correlated with clinicopathological characteristics or clinical outcomes. However in the ESCC patients with family cancer history, PIK3CA mutations were independently correlated with worse overall survival multivariate hazard ratio HR = 10.493, 95% CI: 2.432–45.267, P = 0.002. Compared to normal esophageal tissue, PIK3CA was significantly overexpressed in cancer tissue P



Autor: Wang, Lin; Shan, Ling; Zhang, Shaokai; Ying, Jianming; Xue, Liyan; Yuan, Yanling; Xie, Yongqiang; Lu, Ning

Fuente: https://archive.org/







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