Vol 12: Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces.Reportar como inadecuado



 Vol 12: Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces.


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This article is from BMC Cancer, volume 12.AbstractBackground: Asbestos is classified as a human carcinogen, and studies have consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few studies have evaluated risks in population-based settings where there is a greater variety in the types of occupations, and exposures. Methods: This was a population based case–control study with 1,681 incident cases of lung cancer, and 2,053 controls recruited from 8 Canadian provinces between 1994 and 1997. Self-reported questionnaires were used to elicit a lifetime occupational history, including general tasks, and information for other risk factors. Occupational hygienists, who were blinded to case–control status, assigned asbestos exposures to each job on the basis of i concentration low, medium, high, ii frequency 30% of the time in a normal work week, and iii reliability possible, probable, definite. Logistic regression was used to estimate odds ratios ORs and their corresponding 95% confidence intervals CI. Results: Those occupationally exposed to i low, and ii medium or high concentrations of asbestos had ORs for lung cancer of 1.17 95% CI=0.92 – 1.50 and 2.16 95% CI=1.21-3.88, respectively, relative to those who were unexposed. Medium or high exposure to asbestos roughly doubled the risk for lung cancer across all three smoking pack-year categories. The joint relationship between smoking and asbestos was consistent with a multiplicative risk model. Conclusions: Our findings provide further evidence that exposure to asbestos has contributed to an increased risk of lung cancer in Canadian workplaces, and suggests that nearly 3% of lung cancers among Canadian men are caused by occupational exposure to asbestos.



Autor: Villeneuve, Paul J; Parent, Marie-Elise; Harris, Shelley A; Johnson, Kenneth C

Fuente: https://archive.org/







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