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Publisher: Karger

Issued date: 1997

Citation: Cytogenetics and Cell Genetics, vol. 77, n. 1-2, 1997. Pp. 36

ISSN: 0301-0171

DOI: 10.1159-000317457

Publisher version: http:-dx.doi.org-10.1159-000317457





Autor: Santos, Andrés; Ortiz de Solórzano, Carlos; Malpica, Norberto; Vaquero, Juan José; Pozo, Francisco del; García-Sagredo, José Miguel

Fuente: http://e-archivo.uc3m.es


Introducción



Universidad Carlos III de Madrid Repositorio institucional e-Archivo http:--e-archivo.uc3m.es Área de Imagen e Instrumentación (BiiG) DBIAB - BIIG - Abstracts 1997 Automatic system for FISH cytogenetic analysis Santos, Andrés Karger Cytogenetics and Cell Genetics, vol.
77, n.
1-2, 1997.
Pp.
36 http:--hdl.handle.net-10016-14833 Descargado de e-Archivo, repositorio institucional de la Universidad Carlos III de Madrid Automatic system for FISH cytogenetic analysis 1 1 1 1 1 2 A.
Santos , C.
Ortiz de SoIórzano , N.
Malpica , J.J.
Vaquero , F.
del Pozo , J.M.
García-Sagredo 1 Grupo de Bioingeniería y Telemedicina.
E.T.S.I.
Telecomunicación. 2 Servicio de Genética.
Hospital Ramón y Cajal Madrid (Spain) A new methodology for the automation of FISH spot counting in interphase nuclei will be presented and its performance evaluated. The methodology makes use of digital image processing algorithms for the fully automated detection and scoring of fluorescently tagged chromosome probes on non-mitotic cells. The system achieves automatic image focusing, nuclei detection and segmentation (including with cluster division) and probe segmentation.
The classification steps are based on a discriminant function and a ROC analysis. The performance of the system and its sensibility have been analysed through a control study where the results were known a priori.
They showed the adequacy of the system to be used in clinical environments. 1 ...





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