Vol 10: OsHUS1 Facilitates Accurate Meiotic Recombination in Rice.Reportar como inadecuado



 Vol 10: OsHUS1 Facilitates Accurate Meiotic Recombination in Rice.


Vol 10: OsHUS1 Facilitates Accurate Meiotic Recombination in Rice. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Descargar gratis o leer online en formato PDF el libro: Vol 10: OsHUS1 Facilitates Accurate Meiotic Recombination in Rice.
This article is from PLoS Genetics, volume 10.AbstractMeiotic recombination normally takes place between allelic sequences on homologs. This process can also occur between non-allelic homologous sequences. Such ectopic interaction events can lead to chromosome rearrangements and are normally avoided. However, much remains unknown about how these ectopic interaction events are sensed and eliminated. In this study, using a screen in rice, we characterized a homolog of HUS1 and explored its function in meiotic recombination. In Oshus1 mutants, in conjunction with nearly normal homologous pairing and synapsis, vigorous, aberrant ectopic interactions occurred between nonhomologous chromosomes, leading to multivalent formation and subsequent chromosome fragmentation. These ectopic interactions relied on programed meiotic double strand breaks and were formed in a manner independent of the OsMER3-mediated interference-sensitive crossover pathway. Although early homologous recombination events occurred normally, the number of interference-sensitive crossovers was reduced in the absence of OsHUS1. Together, our results indicate that OsHUS1 might be involved in regulating ectopic interactions during meiosis, probably by forming the canonical RAD9-RAD1-HUS1 9-1-1 complex.



Autor: Che, Lixiao; Wang, Kejian; Tang, Ding; Liu, Qiaoquan; Chen, Xiaojun; Li, Yafei; Hu, Qing; Shen, Yi; Yu, Hengxiu; Gu, Minghong; Cheng, Zhukuan

Fuente: https://archive.org/







Documentos relacionados