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 NMR-Active Nuclei for Biological and Biomedical Applications


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AbstractNuclear magnetic resonance NMR spectroscopy is a principal well-established technique for analysis of chemical, biological, food and environmental samples.  This article provides an overview of the properties and applications of NMR-active nuclei 39 nuclei of 33 different elements used in NMR measurements solution- and solid-state NMR, magnetic resonance spectroscopy, magnetic resonance imaging with biological and biomedical systems and samples.  The samples include biofluids, cells, tissues, organs or whole body from different organisms humans, animals, bacteria, fungi, plants for detecting and quantifying metabolites or environmental samples water, soils, sediments.  Isolated biomolecules peptides, proteins, nucleic acids can be analysed for elucidation of atomic-resolution structure, conformation and dynamics and for characterisation of ligand and drug binding, and of protein-ligand, protein-protein and protein-nucleic acid interactions.  NMR can be used for drug screening and pharmacokinetics and to provide information in the design and discovery of new drugs.  NMR can also measure translocation of ions and small molecules across lipid bilayers and membranes, characterise structure, phase behaviour and dynamics of membranes and elucidate atomic-resolution structure, orientation and dynamics of membrane-embedded peptides and proteins.CitationPatching SG. NMR-Active Nuclei for Biological and Biomedical Applications. Journal of Diagnostic Imaging in Therapy. 2016;3 1: 7-48. http:-dx.doi.org-10.17229-jdit.2016-0618-021



Autor: Simon G. Patching

Fuente: https://archive.org/







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