Vol 12: Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials.Reportar como inadecuado



 Vol 12: Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials.


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This article is from Reproductive Biology and Endocrinology : RB&E, volume 12.AbstractThe current systematic review with meta-analysis of randomized controlled trials RCTs was aimed to evaluate the effects of metformin on reproductive outcomes in patients with polycystic ovary syndrome PCOS who receive gonadotropins for ovulation induction. After systematic review of electronic databases and websites for registration of RCTs, a total of 7 RCTs reporting data on 1023 cycles were included in the final analysis. Descriptive data showed an overall low studies’ quality due to unclear sequence generation and allocation concealment, lack of blinding procedure, incomplete outcome data and several biases and-or confounders. Data synthesis showed that metformin improved live-birth odds ratio OR = 1.94, 95% confidence interval CI 1.10 to 3.44; P = 0.020 and pregnancy OR = 2.25, 95% CI 1.50 to 3.38; P 



Autor: Palomba, Stefano; Falbo, Angela; La Sala, Giovanni B

Fuente: https://archive.org/







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