Vol 12: Metabolic phenotypes in primary unknown metastatic carcinoma.Reportar como inadecuado



 Vol 12: Metabolic phenotypes in primary unknown metastatic carcinoma.


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This article is from Journal of Translational Medicine, volume 12.AbstractBackground: The purpose of this study is to evaluate expression of metabolism-related proteins in primary unknown metastatic carcinoma PUMC and associated implications for treatment. Methods: A tissue microarray containing 77 cases of PUMC was constructed and immunohistochemical staining was used to evaluate expression of the following proteins: Glycolysis-related: Glut-1, carbonic anhydrase CA IX, and monocarboxylate transporter MCT 4; Glutaminolysis-related: glutaminase1 GLS1, glutamate dehydrogenase GDH, and amino acid transporter-2 ASCT2; and Mitochondrial-related: ATP synthase, succinate dehydrogenase SDHA, and SDHB. The association between immunohistochemical staining results and clinicopathologic parameters was evaluated. Results: The expression of metabolism-related proteins was different depending on the histologic subtype. Compared to other subtypes, squamous cell carcinomas SQ expressed more Glut-1 p = 0.028, while adenocarcinomas AD expressed more SDHB in the stroma p = 0.025. The expression of metabolism-related proteins was also different depending on the clinical subtypes. Glut-1 was expressed most in the nodal type and the least in carcinomatosis type, when compared to other subtypes p = 0.021. The metabolic phenotypes also showed other trends: when the stroma showed no glutaminolysis, the tumor mostly invaded lymph node, bone, and brain, while the tumor invaded regions other than lymph node, bone, and brain when the stroma showed glutaminolysis p = 0.003. When the stroma showed the mitochondrial metabolic type, the histologic subtype was mainly AD, but the non-mitochondrial type was associated more with SQ P = 0.049. Conclusion: For PUMC, the expression of metabolism-related proteins, such as Glut-1 and SDHB, differs in the tumor or stroma depending on the clinical and histologic tumor subtype.



Autor: Kim, Hye Min; Kim, Do Hee; Jung, Woo Hee; Koo, Ja Seung

Fuente: https://archive.org/







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