Vol 5: Modulation of the unfolded protein response by the human hepatitis B virus.Reportar como inadecuado



 Vol 5: Modulation of the unfolded protein response by the human hepatitis B virus.


Vol 5: Modulation of the unfolded protein response by the human hepatitis B virus. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Descargar gratis o leer online en formato PDF el libro: Vol 5: Modulation of the unfolded protein response by the human hepatitis B virus.
This article is from Frontiers in Microbiology, volume 5.AbstractDuring productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be folded, quality controlled, assembled and secreted, perturbing the normal function of the endoplasmic reticulum ER. To counteract the ER stress, cells activate specific signaling pathways, designated as the unfolded proteins response UPR, which essentially increase their folding capacity, arrest protein translation, and degrade the excess of misfolded proteins. This cellular defense mechanism may, in turn, affect significantly the virus life-cycle. This review highlights the current understanding of the mechanisms of the ER stress activation by Human Hepatitis B virus HBV, a deadly pathogen affecting more than 350 million people worldwide. Further discussion addresses the latest discoveries regarding the adaptive strategies developed by HBV to manipulate the UPR for its own benefits, the controversies in the field and future perspectives.



Autor: Lazar, Catalin; Uta, Mihaela; Branza-Nichita, Norica

Fuente: https://archive.org/



DESCARGAR PDF




Documentos relacionados