Vol 7: Moxifloxacin resistance in the F15-LAM4-KZN extensively drug-resistant strain of Mycobacterium tuberculosis.Reportar como inadecuado



 Vol 7: Moxifloxacin resistance in the F15-LAM4-KZN extensively drug-resistant strain of Mycobacterium tuberculosis.


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This article is from Infection and Drug Resistance, volume 7.AbstractObjectives: Moxifloxacin MXF has been advocated for the treatment of extensively drug-resistant XDR tuberculosis despite resistance to older-generation fluoroquinolones. We investigated the relationship between the minimum inhibitory concentration MIC of MXF and mutations in the gyrA and gyrB genes in Mycobacterium tuberculosis MTB isolates from KwaZulu-Natal KZN Province of South Africa. Materials and methods: MICs of 56 MTB isolates were compared to the mutations in the quinolone resistance-determining region known to confer fluoroquinolone resistance. Isolates were genotyped by IS6110 restriction fragment length polymorphism analysis. Results: The circulating F15-LAM4-KZN XDR strain circulating in KZN Province harbored the A90V mutation and displayed high-level resistance with MICs of 8 mg-L for ciprofloxacin and ofloxacin and ≥1 mg-L for MXF. Conclusion: The inclusion of MXF in XDR-TB treatment regimens requires careful consideration in our setting, where clinical outcome data in MXF-containing regimens are unavailable.



Autor: Dookie, Navisha; Sturm, A Willem; Moodley, Prashini

Fuente: https://archive.org/







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