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 Vol 7: miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer.


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This article is from OncoTargets and therapy, volume 7.AbstractIn the last decade, cancer research efforts in the field of noncoding microRNA miRNA have been growing exponentially. miRNA-based therapeutics have been tested in both preclinical and clinical settings, and miRNA-based cancer diagnostics and prognostics have moved into clinics to help better manage cancer treatment. A growing body of evidence in recent literature suggests miRNA-129 plays important roles in gastrointestinal cancer, including gastric, colorectal, hepatocellular carcinoma, and esophageal cancer. In this review, we focus on accumulating evidence demonstrating the key roles that miRNA-129 plays in tumorigenesis, disease progression, chemoresistance, proliferation, and cell cycle control. Understanding the emerging roles and mechanisms of miRNA-129 in cancer will help us realize the therapeutic and diagnostic-prognostic potential.



Autor: Fesler, Andrew; Zhai, Haiyan; Ju, Jingfang

Fuente: https://archive.org/







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