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Victor Wünsch Filho ;Revista de Saúde Pública 2013, 47 6

Autor: Raquel da Rocha Paiva Maia



Revista de Saúde Pública ISSN: 0034-8910 Universidade de São Paulo Brasil da Rocha Paiva Maia, Raquel; Wünsch Filho, Victor Infection and childhood leukemia: review of evidence Revista de Saúde Pública, vol.
47, núm.
6, diciembre, 2013, pp.
1172-1185 Universidade de São Paulo São Paulo, Brasil Available in: How to cite Complete issue More information about this article Journals homepage in Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Rev Saúde Pública 2013;47(6):1172-85 Revisão Raquel da Rocha Paiva Maia I Infection and childhood leukemia: review of evidence Victor Wünsch FilhoII DOI: 10.1590-S0034-8910.2013047004753 Infecção e leucemia infantil: revisão das evidências ABSTRACT OBJECTIVE: To analyze studies that evaluated the role of infections as well as indirect measures of exposure to infection in the risk of childhood leukemia, particularly acute lymphoblastic leukemia. METHODS: A search in Medline, Lilacs, and SciELO scientific publication databases initially using the descriptors “childhood leukemia” and “infection” and later searching for the words “childhood leukemia” and “maternal infection or disease” or “breastfeeding” or “daycare attendance” or “vaccination” resulted in 62 publications that met the following inclusion criteria: subject aged ≤ 15 years; specific analysis of cases diagnosed with acute lymphoblastic leukemia or total leukemia; exposure assessment of mothers’ or infants’ to infections (or proxy of infection), and risk of leukemia. RESULTS: Overall, 23 studies that assessed infections in children support the hypothesis that occurrence of infection during early childhood reduces the risk of leukemia, but there are disagreements within and between studies. The evaluat...

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