Vol 36: Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer and the Prevention of Amputation: A cohort study.Reportar como inadecuado



 Vol 36: Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer and the Prevention of Amputation: A cohort study.


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This article is from Diabetes Care, volume 36.AbstractOBJECTIVE: Hyperbaric oxygen HBO is a device that is used to treat foot ulcers. The study goal was to compare the effectiveness of HBO with other conventional therapies administered in a wound care network for the treatment of a diabetic foot ulcer and prevention of lower-extremity amputation. RESEARCH DESIGN AND METHODS: This was a longitudinal observational cohort study. To address treatment selection bias, we used propensity scores to determine the -propensity- that an individual was selected to receive HBO. RESULTS: We studied 6,259 individuals with diabetes, adequate lower limb arterial perfusion, and foot ulcer extending through the dermis, representing 767,060 person-days of wound care. In the propensity score–adjusted models, individuals receiving HBO were less likely to have healing of their foot ulcer hazard ratio 0.68 95% CI 0.63–0.73 and more likely to have an amputation 2.37 1.84–3.04. Additional analyses, including the use of an instrumental variable, were conducted to assess the robustness of our results to unmeasured confounding. HBO was not found to improve the likelihood that a wound might heal or to decrease the likelihood of amputation in any of these analyses. CONCLUSIONS: Use of HBO neither improved the likelihood that a wound would heal nor prevented amputation in a cohort of patients defined by Centers for Medicare and Medicaid Services eligibility criteria. The usefulness of HBO in the treatment of diabetic foot ulcers needs to be reevaluated.



Autor: Margolis, David J.; Gupta, Jayanta; Hoffstad, Ole; Papdopoulos, Maryte; Glick, Henry A.; Thom, Stephen R.; Mitra, Nandita

Fuente: https://archive.org/







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