Vol 102: LINE-1 Hypomethylation is Associated with the Risk of Coronary Heart Disease in Chinese Population.Report as inadecuate



 Vol 102: LINE-1 Hypomethylation is Associated with the Risk of Coronary Heart Disease in Chinese Population.


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This article is from Arquivos Brasileiros de Cardiologia, volume 102.AbstractBackground: Global methylation level in blood leukocyte DNA has been associated with the risk of coronary heart disease CHD, with inconsistent results in various populations. Similar data are lacking in Chinese population where different genetic, lifestyle and environmental factors may affect DNA methylation and its risk relationship with CHD. Objectives: To examine whether global methylation is associated with the risk of CHD in Chinese population. Methods: A total of 334 cases with CHD and 788 healthy controls were included. Global methylation in blood leukocyte DNA was estimated by analyzing LINE-1 repeats using bisulfite pyrosequencing. Results: In an initial analysis restricted to control subjects, LINE-1 level reduced significantly with aging, elevated total cholesterol, and diagnosis of diabetes. In the case-control analysis, reduced LINE-1 methylation was associated with increased risk of CHD; analysis by quartile revealed odds ratios 95%CI of 0.9 0.6-1.4, 1.9 1.3-2.9 and 2.3 1.6-3.5 for the third, second and first lowest quartile Ptrend 0.001, respectively, compared to the fourth highest quartile. Lower



Author: Wei, Li; Liu, Shuchuan; Su, Zhendong; Cheng, Rongchao; Bai, Xiuping; Li, Xueqi

Source: https://archive.org/







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