Vol 11: Lanthanum carbonate prevents accelerated medial calcification in uremic rats: role of osteoclast-like activity.Report as inadecuate



 Vol 11: Lanthanum carbonate prevents accelerated medial calcification in uremic rats: role of osteoclast-like activity.


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This article is from Journal of Translational Medicine, volume 11.AbstractBackground: Arterial medial calcification AMC is frequent prevalence in patients with end stage renal disease. Evidence about hyperphosphatemia induced anabolic crosstalk between osteoblast and osteoclast in AMC of uremia is rare. Lanthanum carbonate as an orally administered phosphate-binding agent to reduce phosphate load and ameliorate AMC, but direct evidence is missing. Methods: Detailed time-course studies were conducted of Sprague–Dawley rats fed with adenine and high phosphate diet to imitate the onset and progression of AMC of uremia. Calcification in great arteries was evaluated by VonKossa’s and Massons trichrome staining. Osteoblast Runx2, Osteocalcin and osteoclast RANKL, Cathepsin K, TRAP related genes were analyzed by Immunohistochemistry and qRT-PCR. Serum PTH, RANKL and OPG levels were detected by ELISA kit. Results: Serum phosphate was markedly increased in CRF group 6.94 ± 0.97 mmol-L and 2%La group 5.12 ± 0.84 mmol-L at week 4, while the latter group diminished significantly 2.92 ± 0.73 mmol-L vs CRF Group 3.48 ± 0.69, p 



Author: Che, Yu; Bing, Chen; Akhtar, Javed; Tingting, Zhao; Kezhou, Yu; Rong, Wang

Source: https://archive.org/







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