Vol 44: Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase PToV-HE protein.Report as inadecuate



 Vol 44: Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase PToV-HE protein.


Vol 44: Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase PToV-HE protein. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Veterinary Research, volume 44.AbstractHemagglutinin-esterases HE are viral envelope proteins present in some members from the toro-, corona- and orthomyxovirus families, all related with enteric and-or respiratory tract infections. HE proteins mediate reversible binding to sialic acid receptor determinants, very abundant glycan residues in the enteric and respiratory tracts. The role of the HE protein during the torovirus infection cycle remains unknown, although it is believed to be important in the natural infection process. The phylogenetic analysis of HE coding sequences from porcine torovirus PToV field strains revealed the existence of two distinct HE lineages. In a previous study, PToV virus strains with HE proteins from the two lineages were found coexisting in a pig herd, and they were even obtained from the same animal at two consecutive sampling time points. In this work, we report antigenic differences between the two HE lineages, and discuss the possible implications that the coexistence of viruses belonging to both lineages might have on the spread and sustainment of PToV infection in the farms.



Author: Pignatelli, Jaime; Alonso-Padilla, Julio; Rodriguez, Dolores

Source: https://archive.org/







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