Vol 8: Long-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma.Report as inadecuate



 Vol 8: Long-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma.


Vol 8: Long-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 8: Long-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma.
This article is from Gut and Liver, volume 8.AbstractBackground-Aims: Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy PDT has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more effective than PDT alone. Methods: In total, 161 patients with cholangiocarcinoma diagnosed between February 1999 and September 2009 were evaluated. Sixteen patients were treated with PDT and chemotherapy group A, and 58 were treated with PDT group B. Results: The median survival was 538 days 95% confidence interval CI, 475.3 to 600.7 in group A and 334 days 95% CI, 252.5 to 415.5 in group B p=0.05. Lymph node metastasis status, serum bilirubin of pretreatment, tumor node metastasis stage, treatment method PDT with chemotherapy vs PDT alone, time to PDT and the number of PDT sessions were prognostic factors with statistical significance in the univariate analysis. A multivariate analysis showed that PDT with chemotherapy and more than two sessions of PDT were significant independent predictors of longer survival in advanced cholangiocarcinoma hazard ratio HR, 2.23; 95% CI, 1.18 to 4.20; p=0.013 vs HR, 1.79; 95% CI, 1.044 to 3.083; p=0.034. Conclusions: PDT with chemotherapy results in longer survival than PDT alone.



Author: Hong, Mi Jin; Cheon, Young Koog; Lee, Eung Jun; Lee, Tae Yoon; Shim, Chan Sup

Source: https://archive.org/







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