Vol 16: Long and noncoding RNAs lnc-RNAs determine androgen receptor dependent gene expression in prostate cancer growth in vivo.Report as inadecuate



 Vol 16: Long and noncoding RNAs lnc-RNAs determine androgen receptor dependent gene expression in prostate cancer growth in vivo.


Vol 16: Long and noncoding RNAs lnc-RNAs determine androgen receptor dependent gene expression in prostate cancer growth in vivo. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 16: Long and noncoding RNAs lnc-RNAs determine androgen receptor dependent gene expression in prostate cancer growth in vivo.
This article is from Asian Journal of Andrology, volume 16.AbstractHyperactive androgen receptor AR activity remains a key determinant of the onset and progression of prostate cancer and resistance to current therapies. The mechanisms governing castrate resistant prostate cancer are poorly understood, but defining these molecular events is essential in order to impact deaths from prostate cancer. Yang et al. demonstrate that two lnc-RNAs known to be overexpressed in therapy resistant prostate cancer, PRNCR1 also known as PCAT8 and PCGEM1, bound to the AR to enhance ligand-dependent and ligand-independent AR gene expression and proliferation of prostate cancer cells.1 The sequence of these interactions involved the binding of PRNCR1 to the acetylated AR and a subsequent association of DOT1L, which was required for the sequential recruitment of the lncRNA PCGEM1 to the AR amino terminus, which in turn was methylated by DOT1L.



Author: Pestell, Richard G; Yu, Zuoren

Source: https://archive.org/







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