Vol 9: Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study.Report as inadecuate



 Vol 9: Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study.


Vol 9: Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study. - Download this document for free, or read online. Document in PDF available to download.

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This article is from PLoS ONE, volume 9.AbstractBackground: Dyslipidemia, typically recognized as high serum triglyceride, high low-density lipoprotein cholesterol LDL-C or low high-density lipoprotein cholesterol HDL-C levels, are associated with nonalcoholic fatty liver disease NAFLD. However, low LDL-C levels could result from defects in lipoprotein metabolism or impaired liver synthetic function, and may serve as ab initio markers for unrecognized liver diseases. Whether such relationships exist in the general population has not been investigated. We hypothesized that despite common conception that low LDL-C is desirable, it might be associated with elevated liver enzymes due to metabolic liver diseases. Methods and Findings: We examined the associations between alanine aminotransferase ALT, aspartate aminotransferase AST and major components of serum lipid profiles in a nationally representative sample of 23,073 individuals, who had no chronic viral hepatitis and were not taking lipid-lowering medications, from the National Health and Nutrition Examination Survey NHANES from 1999 to 2010. ALT and AST exhibited non-linear U-shaped associations with LDL-C and HDL-C, but not with triglyceride. After adjusting for potential confounders, individuals with LDL-C less than 40 and 41–70 mg-dL were associated with 4.2 95% CI 1.5–11.7, p = 0.007 and 1.6 95% CI 1.1–2.5, p = 0.03 times higher odds of abnormal liver enzymes respectively, when compared with those with LDL-C values 71–100 mg-dL reference group. Surprisingly, those with HDL-C levels above 100 mg-dL was associated with 3.2 95% CI 2.1–5.0, p



Author: Jiang, Zhenghui Gordon; Mukamal, Kenneth; Tapper, Elliot; Robson, Simon C.; Tsugawa, Yusuke

Source: https://archive.org/







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