Vol 16: Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment.Report as inadecuate



 Vol 16: Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment.


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This article is from Asian Journal of Andrology, volume 16.AbstractAlthough suppressed serum testosterone T is common in ageing men, only a small proportion of them develop the genuine syndrome of low T associated with diffuse sexual e.g., erectile dysfunction, physical e.g. loss of vigor and frailty and psychological e.g., depression symptoms. This syndrome carries many names, including male menopause or climacterium, andropause and partial androgen deficiency of the ageing male PADAM. Late-onset hypogonadism LOH describes it best and is therefore generally preferred. The decrease of T in LOH is often marginal, and hypogonadism can be either due to primary testicular failure low T, high luteinizing hormone LH or secondary to a hypothalamic-pituitary failure low T, low or inappropriately normal LH. The latter form is more common and it is usually associated with overweight-obesity or chronic diseases e.g., type 2 diabetes mellitus, the metabolic syndrome, cardiovascular and chronic obstructive pulmonary disease, and frailty. A problem with the diagnosis of LOH is that often the symptoms in 20%–40% of unselected men and low circulating T in 20% of men 70 years of age do not coincide in the same individual. The European Male Ageing Study EMAS has recently defined the strict diagnostic criteria for LOH to include the simultaneous presence of reproducibly low serum T total T



Author: Huhtaniemi, Ilpo

Source: https://archive.org/







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