Vol 9: Lactobacillus rhamnosus GG Protects against Non-Alcoholic Fatty Liver Disease in Mice.Report as inadecuate



 Vol 9: Lactobacillus rhamnosus GG Protects against Non-Alcoholic Fatty Liver Disease in Mice.


Vol 9: Lactobacillus rhamnosus GG Protects against Non-Alcoholic Fatty Liver Disease in Mice. - Download this document for free, or read online. Document in PDF available to download.

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This article is from PLoS ONE, volume 9.AbstractObjective: Experimental evidence revealed that obesity-associated non-alcoholic fatty liver disease NAFLD is linked to changes in intestinal permeability and translocation of bacterial products to the liver. Hitherto, no reliable therapy is available except for weight reduction. Within this study, we examined the possible effect of the probiotic bacterial strain Lactobacillus rhamnosus GG LGG as protective agent against experimental NAFLD in a mouse model. Methods: Experimental NAFLD was induced by a high-fructose diet over eight weeks in C57BL-J6 mice. Fructose was administered via the drinking water containing 30% fructose with or without LGG at a concentration resulting in approximately 5×107 colony forming units-g body weight. Mice were examined for changes in small intestinal microbiota, gut barrier function, lipopolysaccharide LPS concentrations in the portal vein, liver inflammation and fat accumulation in the liver. Results: LGG increased beneficial bacteria in the distal small intestine. Moreover, LGG reduced duodenal IκB protein levels and restored the duodenal tight junction protein concentration. Portal LPS P≤0.05 was reduced and tended to attenuate TNF-α, IL-8R and IL-1β mRNA expression in the liver feeding a high-fructose diet supplemented with LGG. Furthermore liver fat accumulation and portal alanine-aminotransferase concentrations P≤0.05 were attenuated in mice fed the high-fructose diet and LGG. Conclusions: We show for the first time that LGG protects mice from NAFLD induced by a high-fructose diet. The underlying mechanisms of protection likely involve an increase of beneficial bacteria, restoration of gut barrier function and subsequent attenuation of liver inflammation and steatosis.



Author: Ritze, Yvonne; Bardos, Gyongyi; Claus, Anke; Ehrmann, Veronika; Bergheim, Ina; Schwiertz, Andreas; Bischoff, Stephan C.

Source: https://archive.org/







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