Vol 9: Lymph Node Ratio for Postoperative Staging of Laryngeal Squamous Cell Carcinoma with Lymph Node Metastasis.Report as inadecuate



 Vol 9: Lymph Node Ratio for Postoperative Staging of Laryngeal Squamous Cell Carcinoma with Lymph Node Metastasis.


Vol 9: Lymph Node Ratio for Postoperative Staging of Laryngeal Squamous Cell Carcinoma with Lymph Node Metastasis. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 9: Lymph Node Ratio for Postoperative Staging of Laryngeal Squamous Cell Carcinoma with Lymph Node Metastasis.
This article is from PLoS ONE, volume 9.AbstractBackground: Lymph node metastasis has a significant impact on laryngeal cancer prognosis. The role of lymph node ratio LNR, ratio of metastatic to examined nodes in the staging of laryngeal cancer was not reported. Patients and Methods: Records of laryngeal cancer patients with lymph node involvement from Surveillance, Epidemiology, and End Results database SEER, training set, N = 1963 and Fudan University Shanghai Cancer Center FDSCC, validating set, N = 27 were analyzed for the prognostic value of LNR. Kaplan–Meier survival estimates, the Log-rank χ2 test and Cox proportional hazards model were used for univariate and multivariate analysis. Optimal LNR cutoff points were identified by X-tile. Results: Optimal LNR cutoff points classified patients into three risk groups R1 ≤0.09, R2 0.09–0.20 and R3 0.20, corresponding to 5-year cause-specific survival and overall survival in SEER patients of 55.1%, 40.2%, 28.8% and 43.1%, 31.5%, 21.8%, 2-year disease free survival and disease specific survival in FDSCC patients of 74.1%, 62.5%, 50.0%, and 67.7%, 43.2%, 25.0%, respectively. R3 stratified more high risk patients than N3 with the same survival rate, and R classification clearly separated N2 patients to 3 risk groups and N1 patients to 2 risk groups R1–2 and R3. Conclusions: R classification is a significant prognostic factor of laryngeal cancer and should be used as a complementary staging system of N classification.



Author: Wang, Yu-Long; Li, Duan-Shu; Wang, Yu; Wang, Zhuo-Ying; Ji, Qing-Hai

Source: https://archive.org/







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