Vol 47: Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women.Report as inadecuate



 Vol 47: Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women.


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This article is from Journal of Preventive Medicine and Public Health, volume 47.AbstractObjectives: To evaluate the association between fracture risk and levothyroxine use in elderly women with hypothyroidism, according to previous osteoporosis history. Methods: We conducted a cohort study from the Korean Health Insurance Review and Assessment Service claims database from January 2005 to June 2006. The study population comprised women aged ≥65 years who had been diagnosed with hypothyroidism and prescribed levothyroxine monotherapy. We excluded patients who met any of the following criteria: previous fracture history, hyperthyroidism, thyroid cancer, or pituitary disorder; low levothyroxine adherence; or a follow-up period 150 µg-d. The hazard ratios HRs and 95% confidence intervals CIs were estimated with the Cox proportional hazard model, and subgroup analyses were performed according to the osteoporosis history and osteoporosis-specific drug prescription status. Results: Among 11 155 cohort participants, 35.6% had previous histories of osteoporosis. The adjusted HR of fracture for the 150 µg-d group, compared with the 51 to 100 µg-d group, was 1.56 95% CI, 1.03 to 2.37 in osteoporosis subgroup. In the highly probable osteoporosis subgroup, restricted to patients who were concurrently prescribed osteoporosis-specific drugs, the adjusted HR of fracture for the 150 µg-d group, compared with the 51 to 100 µg-d group, was 1.93 95% CI, 1.14 to 3.26. Conclusions: While further studies are needed, physicians should be concerned about potential levothyroxine overtreatment in elderly osteoporosis patients.



Author: Ko, Young-Jin; Kim, Ji Young; Lee, Joongyub; Song, Hong-Ji; Kim, Ju-Young; Choi, Nam-Kyong; Park, Byung-Joo

Source: https://archive.org/







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