Vol 7: Loss of Heterozygosities in Five Tumor Suppressor Genes FHIT Gene, p16, pRb, E-Cadherin and p53 in Thyroid Tumors.Report as inadecuate



 Vol 7: Loss of Heterozygosities in Five Tumor Suppressor Genes FHIT Gene, p16, pRb, E-Cadherin and p53 in Thyroid Tumors.


Vol 7: Loss of Heterozygosities in Five Tumor Suppressor Genes FHIT Gene, p16, pRb, E-Cadherin and p53 in Thyroid Tumors. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 7: Loss of Heterozygosities in Five Tumor Suppressor Genes FHIT Gene, p16, pRb, E-Cadherin and p53 in Thyroid Tumors.
This article is from Clinical and Experimental Otorhinolaryngology, volume 7.AbstractObjectives: To evaluate the loss of heterozygosities LOH of chromosomes 3p14 FHIT gene, 9p21 p16, 13q21 pRb, 6q22 E-cadherin and 17p13 p53 in various thyroid tumors. Methods: Eighty thyroid tumor cases 20 follicular adenomas, 10 follicular carcinomas, and 50 papillary carcinomas have been analyzed for the presence of LOH in chromosomes 3p14, 9p21, 13q21, 6q22, and 17p13 allelic loss, using microsatellite markers and DNA obtained from formalin-fixed paraffin-embedded archival tissues. Results: LOH on 3p14 was found in 10.5%, 33.3%, and 30.4% of follicular adenomas, follicular carcinomas, and papillary carcinomas, respectively. LOH on 9p21 was detected in 6%, 44.4%, and 47.8%, respectively. LOH on pRb gene was found in 5.3%, 20.0%, and 35.4%, respectively. LOH on E-cadherin gene was found in 5.3%, 22.2%, and 43.8%, respectively. LOH on 17p13 was detected in 0%, 40%, and 45.8%, respectively. LOH in FHIT gene, p16, pRb, E-cadherin, and p53 genes were more frequently identified in follicular carcinoma and papillary carcinoma than in follicular adenoma. Conclusion: LOH results of the five tumor suppressor genes FHIT gene, p16, pRb, E-cadherin, and p53 showed statistical differences between benign tumor and malignant tumor. Among papillary carcinoma, LOH in p16, E-cadherin and p53 genes well correlated with poorly differentiated grade, and LOH of E-cadherin was associated with lymph node metastasis.



Author: Kim, Jin Hwan; Choi, Kyu Young; Lee, Dong Jin; Rho, Young-Soo; Jo, Sung-Jin

Source: https://archive.org/







Related documents